2003•Korean Journal of PediatricsOpen access

Increased Matrix Metalloproteinase-9 and Tissue Inhibitor of Metalloproteinase-1 Levels in the Cerebrospinal Fluid from Children with Aseptic Meningitis

Ju Hee Yang, Min Hyuk Park, Jung‐Yeon Shim, Hye Lim Jung, Moon Soo Park, Dong Hyuck Keum

Abstract

접수 : 2003년 3월 4일, 승인 : 2003년 5월 6일 책임저자 :심정연, 성균관의대 강북삼성병원 소아과 Tel : 02)2001-2207 Fax : 02)2001-2199 E-mail : jyssim@hotmail.com 단백질이 뇌척수액으로 이동하여 혈관성 뇌부종을 일으키고, 심 하면 신경학적 장애가 나타날 수 있다 1, 2) . Matrix metalloproteinase(MMP)는 세포외 기질을 분해하는 단백분해 효소로서 중성백혈구, 신경원세포, 신경교세포, 혈관 평활근세포, 내피세포 에서 만들어진다 3-5) . MMP는 현재까지 20종류가 알려져 있으며 기질선호도에 따라 collagenase(MMP-1, MMP-8, MMP-13, MMP-18), gelatinase(MMP-2, MMP-9), stromelysin(MMP무균성 뇌수막염 소아에서 뇌척수액내 Matrix Metalloproteinase(MMP)-9과 Tissue Inhibitor of Metalloproteinase(TIMP)-1의 증가

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Key concepts: Matrix metalloproteinase, Tissue inhibitor of metalloproteinase, Medicine, Metalloproteinase, Collagenase, Gelatinase, Aseptic meningitis, Matrix Metalloproteinase 3