Cadmium induced histopathological changes in the stomach and small intestine of Swiss albino mice Mus musculus

The results on the effect of oral administration of cadmium chloride on the histomorphology of the stomach and small intestine of Swiss albino mice revealed severe histopathological effects in the tissues of both stomach and small intestine. There is marked atrophy of musculature, and disintegration of sub-mucosal and mucosal tissues, distortion of villi with disintegration of mucosal epithelial cells characterized by cytoplasmic vacuolization, nuclear pycnosis and nuclear fragmentation. A significant damage in the Brunner’s gland and crypts of Liberkuhn has been observed.