2010•Unpublished venueRequires access
Destruction of mature Haemophilus influenzae biofilms by azithromycin.
Ying Wang, Wang Dong, You-ning Liu, Liangan Chen
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Abstract
OBJECTIVE To determine the activity of azithromycin on bacterial biofilms formed by Haemophilus Influenzae in vitro.METHODS The destruction of different concentrations azithromycin on H.influenzae biofilms was evaluated through crystal violet assay and scanning electron microscopy,viable cells counting in biofilms was also carried out.RESULTS Optical density of biofilms and viable cells counting was significantly decreased at the concentration of 64~1/64 MIC for azithromycin,and biofilm structure was destroyed by azithromycin at concentration of 10 folds of MIC.CONCLUSIONS Azithromycin is able to interfere with adhesion,damage the structure of biofilm,and reduce viable cells counting at high concentrations.