Polymorphism of angiotensin-converting enzyme gene and type 2 diabetes.

Objective:To explore the association of angiotensin converting enzyme(ACE)gene polymorphism with ACE serum level and susceptibility of type 2 diabetes.Methods:287 type 2 diabetes(T2D)patients and 307 healthy individuals were enrolled in the study,and divided into T2D group and control group.The polymerase chain reaction(PCR)was applied to detect polymorphism of Alu repeated sequence insertion/deletion(I/D)in ACE gene,the activity of ACE and lipid level were detected by automatic biochemical ana-lyzer,and the SPSS10.0 software was applied to analyze the relationship between frequencies of ACE genotypes and its activity,lipid level and the occurrence of T2D.Results:There was no difference in I/D polymorphism of ACE gene between the T2D group(DD:13.36%,ID:45.93%,II:40.72%)and control group(DD:13.24%,ID:43.90%,II:42.86%).There was significant difference of ACE activity between T2D patients with different genotypes(P0.01).There was significant difference of HDL level between II and DD genotype in group of T2D.Conclusion:The DD genotype or D allele of ACE gene was related with its activity and the HDL level,however ACE I/D polymorphism wasn't the risk of the occurrence of T2D.