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1998•Indian Journal of Pharmaceutical SciencesRequires access

Synthesis, Biological Evaluation And QSAR Analysis Of Some New Derivatives Of Ketoprofen And Flurbiprofen

Neha Kawathekar, Sanjeev Chaturvedi

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Abstract

New derivatives of ketoprofen and flurbiprofen were synthesized by Mannich reaction. The Mannich base amides of ketoprofen and flurbiprofen were synthesized using different amines. These were then evaluated for analgesic, anti-inflammatory, ulcerogenic activities and quantitative structure-activity relationship was analysed. Some of the derivatives were found to be potent with practically no ulcerogenic activity.

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What this paper is about

New derivatives of ketoprofen and flurbiprofen were synthesized by Mannich reaction. The Mannich base amides of ketoprofen and flurbiprofen were synthesized using different amines. These were then evaluated for analgesic, anti-inflammatory, ulcerogenic activities and quantitative structure-activity relationship was analysed. Some of the derivatives were found to be potent with practically no ulcerogenic activity.

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Available abstract

New derivatives of ketoprofen and flurbiprofen were synthesized by Mannich reaction. The Mannich base amides of ketoprofen and flurbiprofen were synthesized using different amines. These were then evaluated for analgesic, anti-inflammatory, ulcerogenic activities and quantitative structure-activity relationship was analysed. Some of the derivatives were found to be potent with practically no ulcerogenic activity.

Key concepts: Flurbiprofen, Ketoprofen, Chemistry, Mannich reaction, Analgesic, Quantitative structure–activity relationship, Pharmacology, Combinatorial chemistry

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