2012•SHAREOK (University of Oklahoma; Oklahoma State University; Central Oklahoma University)Requires access
Roles of Manduca sexta serpin-8 and hemolymph proteinase-1 in the prophenoloxidase activation system
Yang, Fan
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Abstract
Melanization (prophenoloxidase activation) is a major innate immune response in insects, which produces highly toxic and reactive compounds around the wounding or infection. It involves an extracellular serine proteinase pathway which rapidly amplifies responses to infection and stimulate killing of pathogens. Inhibitory regulation of the proteinases by serine proteinase inhibitors (serpins) is important for ensuring a localized defense response.