Transfersomes: Ultra Deformable Vesicular Carrier Systems in Transdermal Drug Delivery System

In vesicular drug carrier systems transfersomes (ultra-deformable carrier systems) are novel carriers, are composed of phospholipid, surfactant, water enhanced transdermal drug delivery systems(TDDS). Transfersomes are efficient in delivering the low molecular weight and as well as high molecular weight drugs through skin, consisting of hydrophobic and hydrophilic moieties together and has a result wide range of solubility. This vesicular transfersomes can deform and pass through narrow constriction (about 10 times less than their own diameter) without measurable loss, This high deformability gives better penetration of intact vesicles, and transfersomes are highly flexibility of particles, so drug targeting can be achieved by this type of delivery systems. Recently various approaches have been used to augment the transdermal delivery of bioactive, they include iontophoresis, electrophoresis, sonophorosis, chemical permeation enhancers, microneedle systems. eg: Analgesics, Anesthetic, Corticosteroids, sex Harmones, Anticancer, Insulin. transferosomes have beneficial advantages over the vesicular systems, higher stability, systemic drug release possible to other than vesicular systems