Review on Immobilization of Nanoparticles for Fabrication of Glucose Biosensor

Glucose biosensor has been improvised from time to time in order to provide fast and accurate detection of glucose concentration especially for diabetic patients. Recently, nanoparticles have rising attention engaging with biosensor application. Nanoparticles serve as the carrier of enzyme immobilization whereas; enzyme is a biological catalyst that reacts with specific substrate in metabolic reaction. Glucose oxidase (GOx) in particular, is the most common enzyme used for fabrication of biosensor. Glucose measurement was done by using amperometric measurement that converted corresponding biochemical reaction between glucose and GOx into electrical output. Response behavior studies were conducted in order to compare the successfulness of GOx immobilization onto GOx-biosensor. Immobilization of glucose oxidase onto nanoparticles can lead towards tremendous impacts especially in new, high sensitivity biosensor.