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2009•Research Journal of Pharmacy and TechnologyRequires access

Simultaneous Estimation of Omeprazole and Cisapride in Pharmaceutical Dosage Form

Vijaya P. Godse, Mane Shrinivas R, Bhosale Av, AV Kasture

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Abstract

A simple, rapid, reproducible and economical procedure for routine simultaneous analysis of Omeprazole and Cisapride in oral dosage form has been developed using multicomponent mode of analysis. The method is based on the native Ultraviolet absorbance maximas of the two drugs in methanol. The interference among the components of the formulations was reduced by employing five mixed standards and four sampling wavelengths of 214.5nm, 221.5nm, 230nm and 240nm.The method has been validated statistically. The recovery was between 99 to 101%.

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What this paper is about

A simple, rapid, reproducible and economical procedure for routine simultaneous analysis of Omeprazole and Cisapride in oral dosage form has been developed using multicomponent mode of analysis. The method is based on the native Ultraviolet absorbance maximas of the two drugs in methanol. The interference among the components of the formulations was reduced by employing five mixed standards and four sampling wavelengths of 214.5nm, 221.5nm, 230nm and 240nm.The method has been validated statistically. The recovery was between 99 to 101%.

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Available abstract

A simple, rapid, reproducible and economical procedure for routine simultaneous analysis of Omeprazole and Cisapride in oral dosage form has been developed using multicomponent mode of analysis. The method is based on the native Ultraviolet absorbance maximas of the two drugs in methanol. The interference among the components of the formulations was reduced by employing five mixed standards and four sampling wavelengths of 214.5nm, 221.5nm, 230nm and 240nm.The method has been validated statistically. The recovery was between 99 to 101%.

Key concepts: Cisapride, Omeprazole, Dosage form, Absorbance, Chromatography, Medicine, Mathematics, Pharmacology

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