1992•Journal of the American Society of NephrologyRequires access

Intercellular adhesion molecules and vascular cell adhesion molecule-1 and the kidney.

Rudolf P. Wüthrich

Abstract

Adhesion molecules such as intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 are expressed in the kidney and are regulated by proinflammatory cytokines. These adhesion molecules play an important role in the binding and activation process of leukocytes and are of importance in inflammatory kidney diseases. This review article describes current knowledge regarding the structure, expression, and functional role of adhesion molecules and their significance in immune-mediated renal diseases.

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Key concepts: Cell adhesion molecule, Proinflammatory cytokine, Soluble cell adhesion molecules, Intercellular Adhesion Molecule-1, Intercellular adhesion molecule, Adhesion, Cell adhesion, Cell biology