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BODY RETENTION OF HYDROXOCOBALAMIN AND CYANOCOBALAMIN

Lewis M. Schiffer, Donald Price, S.H. Cohn, E.P. Cronkite

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Abstract

Hydroxocobalamin has been suggested as a replacement for cyanocobalamin as a vitamin B/sub 12/ compound for the treatment of pernicious anemia. Studies in patients with pernicious anemia given Co/sup 60/-labeled cyanocobalamin or Co/ sup 58/-labeled hydroxocobalamin, and followed for over 200 days by means of whole-body counting with a gamma spectrometer, showed that the two compounds have similar biologic half lives once absorption is completed. (C.H.)

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What this paper is about

Hydroxocobalamin has been suggested as a replacement for cyanocobalamin as a vitamin B/sub 12/ compound for the treatment of pernicious anemia. Studies in patients with pernicious anemia given Co/sup 60/-labeled cyanocobalamin or Co/ sup 58/-labeled hydroxocobalamin, and followed for over 200 days by means of whole-body counting with a gamma spectrometer, showed that the two compounds have similar biologic half lives once absorption is completed. (C.H.)

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Available abstract

Hydroxocobalamin has been suggested as a replacement for cyanocobalamin as a vitamin B/sub 12/ compound for the treatment of pernicious anemia. Studies in patients with pernicious anemia given Co/sup 60/-labeled cyanocobalamin or Co/ sup 58/-labeled hydroxocobalamin, and followed for over 200 days by means of whole-body counting with a gamma spectrometer, showed that the two compounds have similar biologic half lives once absorption is completed. (C.H.)

Key concepts: Hydroxocobalamin, pernicious anemia, Cyanocobalamin, Vitamin B12, Hematinic, Chemistry, Anemia, Vitamin b

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