Elimination of Trichinella spiralis larvae by baijiu in experimentally infected mice.

Objective To observe the effect of baijiu(Chinese distilled alcohol)on Trichinella spiralis larvae in experimentally infected mice.Methods Eighty male Kunming mice were first fed meat containing T.spiralis muscle larvae(500 larvae per mouse).All mice were then randomly divided into 8 groups(10 mice per group).Each group of mice was orally inoculated with 0.2 ml or 0.4 ml of 0.62,0.54 and 0.46 baijiu(volume fractions of alcohol)or saline(control).Five infected mice in each group were sacrificed 7 days and 42 days post-infection and examined for the intestinal adult worms and muscle larvae of T.spiralis.Results In mice inoculated with 0.2 ml of 0.62,0.54 and 0.46 baijiu,the number of intestinal adult worms was 80.00±11.25,208.00±22.89,and 256.00±69.37,and the number of muscle larvae was 37 993.60±296.50,54 166.60±2951.98,and 63 808.40±2442.81,respectively.In mice inoculated with 0.4 ml of 0.62,0.54,and 0.46 baijiu,the number of intestinal adults was 21.00±11.83,87.00±27.66,and 112.00±25.38,and the number of muscle larvae was 24 691.20±4 628.14,47 266.60±1 955.49,and 50 833.40±2 211.50,respectively.The number of intestinal adults and muscle larvae in the control group given saline was 312.00±76.93 and 81 050.00±13 157.74,respectively.Differences between the experimental and control groups were statistically significant(P0.05).The number of intestinal adult worms and muscle larvae in the infected mice inoculated with baijiu decreased with an increase in the dose of baijiu(P0.05).Conclusion The ability of baijiu to eradicate muscle larvae in mice infected with T.spiralis relates to the alcohol content,and inoculation of mice with baijiu decreased the severity of T.spiralis infection.