Histologic variability in the iliac Crest Biopsy of Postmenopausal and Osteoporotic Women

Many investigations have been carried out on osteoporosis and showed this disorder in a new light.Postmenopausal osteoporosis is the commonest type of osteoporosis in clinical practice.At the cellular level, osteoporosis is the consequence of imbalance or uncoupling of osteoblastic bone deposition and osteoclastic bone resorption.Histomorphometric studies have demonstarted considerable heterogenity in the activity of bone cells and bone turnover in osteoporosis.it is well established that the diagnosis of osteoporosis and fracture risk assessment are based on bone density measurement.Association of bone histology characteristics and their impact on bone density remains to be elucidated and was addressed in this study.Forty-three postmenopausal women underwent transiliac bone biopsy in the course of diagnostic procedures and the following static histomorphometric parameters were assessed by optical grid:bone volume, osteoblast and osteoid surface, osteoid thickness and osteoclast surface.Bone mineral density (BMD)was measured by DEXA at the lumbar spine and hip.The published reference data for histomorphometric indices were used for comparison of own results.Data were analysed according to normal, osteopenic and osteoporotic BMD results, and showed no diferencefor any of the histomorphometric patients.