호흡기질환 환자로부터 분리된 Mycoplasma pneumoniae의 tetracycline과 erythromycin에 대한 저항성 변이

One hundred and twenty three strains of Mycoplasma pneumoniae were isolated from patients with respiratory diseases from February 2002 to April 2005 in Busan, Korea. The MICs of tetracycline and erythromycin up to 90% of the 123 M. pneumoniae isolates tested were 0.5~1.0, and 0.5~512 ㎍/ml, respectively. Plasmid DNA was not isolated from all of the M. pneumoniae isolates. Out of 123 strains of M. pneumoniae, 57 (46.3%) stains contain tetM gene on their chromosomal DNA, and 60 (48.8%) strains were mutated in domain V of 23S rRNA for erythromycin resistance. Out of 63 strains of M. pneumoniae which were not mutated in domain V of 23S rRNA for erythromycin resistance, 36 (57.1%) strains contained tetM gene, and out of 60 strains of M. pneumoniae which were mutated in domain V of 23S rRNA for erythromycin resistance, 21 (35.0%) strains contained tetM gene. These results suggest that the isolation rate of erythromycin and tetracycline resistant M. pneumoniae is higher than those of other countries, and erythromycin and tetracycline are not first choice drug for M. pneumoniae infection in Korea, and it need confirm by a nationwide surveilance of antimicrobial resistance.