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1997•Indian Journal of Pharmaceutical SciencesRequires access

CYTOTOXICITY OF THE ESSENTIAL OILS OF CYMBOPOGON CITRATUS AND OCIMUM GRATISSIMUM

Nawal Kishore Dubey, Narra Kishore, J. B. Varma, Sook‐Young Lee

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Abstract

The essential oils isolated from leaves of Cymbopogon citratus and Ocimum gratissimum have been tested for their cytotoxic activity against P388 leukemia cells. The IC50 of the Cymbopogon oil was found to be 5.7 µg/ml while that of Ocimum oil was 10.8 µg/ml. The mixture of the oils (1:1 v/v) showed an IC50 value of 10.2 µg/ml and there was no synergism in the cytotoxic activity. The oils were standardized by their physico- chemical properties.

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What this paper is about

The essential oils isolated from leaves of Cymbopogon citratus and Ocimum gratissimum have been tested for their cytotoxic activity against P388 leukemia cells. The IC50 of the Cymbopogon oil was found to be 5.7 µg/ml while that of Ocimum oil was 10.8 µg/ml. The mixture of the oils (1:1 v/v) showed an IC50 value of 10.2 µg/ml and there was no synergism in the cytotoxic activity. The oils were standardized by their physico- chemical properties.

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Available abstract

The essential oils isolated from leaves of Cymbopogon citratus and Ocimum gratissimum have been tested for their cytotoxic activity against P388 leukemia cells. The IC50 of the Cymbopogon oil was found to be 5.7 µg/ml while that of Ocimum oil was 10.8 µg/ml. The mixture of the oils (1:1 v/v) showed an IC50 value of 10.2 µg/ml and there was no synergism in the cytotoxic activity. The oils were standardized by their physico- chemical properties.

Key concepts: Cymbopogon citratus, Ocimum gratissimum, Traditional medicine, Essential oil, Ocimum, Chemistry, Eugenol, Cytotoxicity

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