Synthesis of charged cyclodextrin highly soluble in organic solvents for enantiomer separations in capillary electrophoresis

Synthesis of charged cyclodextrin highly soluble in organic solvents was\nmade by exchanging the inorganic counter ion (Na+) of heptakis (2,3-di-Omethyl-\n6-O-sulfo)-β-CD (Na7HDMS) with tetrabutylammonium (TBA+), to\nproduce TBA7HDMS. The same ion exchange was used to synthesize the TBA\nsalts of the analogous CDs TBA6HxDMS and TBA8ODMS. Indirect-UV\ndetection capillary electrophoresis (CE) and 1H NMR were used as the\ncharacterization methods.\nSeparations of thirteen pharmaceuticals were made using TBA7HDMS as\nthe chiral resolving agent in aqueous CE. On the other hand, a set of twenty\npharmaceuticals was used for the enantiomer separations in non-aqueous CE\n(NACE). Comparison between the results obtained with TBA7HDMS in aqueous\nand non-aqueous CE were made. In addition, comparison between the results\nobtained with TBA7HDMS and Na7HDMS in aqueous and non-aqueous CE were\nmade as well.