DNA damage of monocrotophos on mice.

Objective To explore the genotoxicity of monocrotophos on mice.Methods Fifty mice were randomly divided into five groups.The experimental groups were given monocrotophos by gavage at several doses of 0.00,0.25,0.50,1.00 and 2.00 mg·kg-1 respectively,one time a day for fourteen days.The control group was given saline by intragastric administration.Bone marrow micronuclei test and single cell gel electrophoresis were applied to test the genotoxicity.Results Compared with the control group,an increase in the rate of micronuclei and the DNA damage of peripheral lymphocytes in experimental groups were found(P0.05,P0.01).As to the rate of micronuclei and DNA damage,an obvious dose-effect relationship was showed.Conclusion Monocrotophos has genotoxic effect on mice.