1989•American Journal of Tropical Medicine and HygieneRequires access

A Specific Diagnostic Antigen of Echinococcus granulosus with an Apparent Molecular Weight of 8 kDa

Shirley E. Maddison, Susan B. Slemenda, Peter M. Schantz, Janet A. Fried, Marianna Wilson, Victor C. W. Tsang

Abstract

An echinococcus antigen with an apparent molecular weight of 8 kDa was identified as diagnostically important. An immunoblot assay using this antigen was 91% sensitive for surgically confirmed Echinococcus granulosus hydatid disease of the liver. Specificity was 100% for echinococcosis. Marked cross-reactivity was observed with serum specimens from patients with E. multilocularis and E. vogeli infections. The 8 kDa component was not related to the widely recognized echinococcus antigen 5.

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Key concepts: Echinococcus granulosus, Antigen, Echinococcus multilocularis, Echinococcus, Echinococcosis, Biology, Pathology, Helminthiasis