2002•한국발생생물학회 심포지움Requires access
Genetic Reprogramming after Somatic Cell cloning
X. Cindy Tian, Jie Xu, Fei Xue, Chikara Kubota, Fuliang Du, Xianzhong Yang
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Abstract
Cloning by nuclear transfer in mammals using somatic cells has enormous potential applications. However, somatic cloning has been inefficient in all species in which NT is successful. High abortion and fetal death rates have been observed. These developmental defects have been attributed to incomplete nuclear reprogramming by the somatic cloning process. In this review, we will discuss studies conducted in our labs to understand the nuclear reprogramming process.