2014•Jiefangjun yixue zazhiRequires access
Clinical analysis of hepatic dysfunction after transcatheter arterial chemoembolization in patients with primary liver cancer
Lin Zhou, Huaming Wang, Ding-lun Ai, Yun Zhao, Lin-Zhi Zhang, Qiang Yu, Bin Yang, Xiaoming Peng, WANG Jingyan, Chunzi Liu
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Abstract
Objective To analyze the correlation between clinical features and hepatic dysfunction after transcatheter arterial chemoembolization (TACE) in patients with primary liver cancer (PLC). Methods Two hundred and fifty-one PLC patients from Apr. 2012 to Oct. 2012 at 302 Hospital treated with TACE were retrospectively analyzed. χ2 test and logistic regression model were used to assess the correlation between clinical features and hepatic dysfunction after TACE. Results Forty out of 251 patients (15.9%) presented with hepatic dysfunction after TACE. Univariate analysis showed that the size of tumor diameter, Child- Pugh grade, cholinesterase level and portal vein tumor thrombosis (PVTT) were associated with hepatic dysfunction after TACE in PLC patients. Multivariate analysis showed that Child-Pugh grade B, tumor diameter ≥10cm and low cholinesterase level were risk factors associated with hepatic dysfunction after TACE in PLC patients. Conclusion TACE should be carefully performed to avoid hepatic dysfunction in PLC patients with tumor diameter ≥10cm, Child-Pugh grade B and low cholinesterase level.
DOI: 10.11855/j.issn.0577-7402.2014.02.14