2010•Research Journal of Pharmaceutical Dosage Forms and TechnologyRequires access
Design and Evaluation of the Fast Dissolving Tablets of Aceclofenac by Sublimation Technique
Sumanta Malakar, Pramod Kumar, Suresh V Kulkarni, B. Someshwara Rao, Amit S Yadav
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Abstract
The purpose of this study was to formulate and evaluate fast dissolving tablet of aceclofenac by sublimation technology using camphor. Sodium starch glycolate and crospovidone were used as superdisintegrants. Tablets were prepared by wet granulation technique. The granules were evaluated for angle of repose, bulk density, tapped density and compressibility index. Tablets were evaluated for weight variation, hardness, friability, drug content, wetting time, in vitro dispersion and in vitro dissolution. In vitro release studies were performed using USP XXII dissolution apparatus type II (Electro lab, Mumbai, India) paddle method in 900 ml of pH-7.4 at 75 rpm. Among all the formulation, F-6 shows 83.26% release at the end of 22 min. Thus, F-6 was considered as the best among the other formulations. The selected formulation F-6 was subjected to stability studies for three months, which showed stability with respect to release pattern.