Comparative efficacy of doramectin and ivermectin in rabbit mange

The comparative efficacy of drug doramectin and ivermectin was evaluated against Notoedrus cati var cuniculi in rabbits. For this, 18 rabbits severely infected with N. cati were divided into three groups (six animals in each group). Group 1 and Group 2 were treated with doramectin and ivermectin @ 400 µgkg−1 of body weight subcutaneously, respectively, while Group 3 was kept as infected control and injected normal saline (Placebo). The rate of cure was assessed on the basis of decrease in mite count in skin scrapings and clinical improvement. Complete absence of mites was observed between 9-12 days in doramectin and 15 days in ivermectin treatment group. The rabbits of doramectin treated group showed complete recovery with new hair growth by day 21 of application while ivermectin treated animal showed the same by day 30. The animals in infected group continued to show depreciation in their body condition and two heavily infested rabbits died.