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2013•International Journal of Drug Development and ResearchRequires access

BROMOBENZENE: A HEPATOTOXIN

Mahima Vedi, Sabina Evan Prince, Mahaboobkhan Rasool

Open publisher page 1 citations

Abstract

Liver damage can be induced by drugs or chemicals resulting from overdose or workplace exposure. Bromobenzene is an efficient model to perform studies on hepatotoxicity. After biotransformation into liver,it causes production of reactive oxygen species (ROS). Organs that have been found to be affected due to bromobenzene induced toxicity are liver, kidney and lungs. In the following review, mechanisms and various genes involved in the bromobenzene induced hepatotoxicity have been discussed. Also, the toxicokinetics, involving absorption, metabolism and elimination of bromobenzene from the body have been reviewed in this article. Various herbal extracts and chemicals have been found to exhibit protective effect against bromobenzene induced liver injury proving their potential in use as hepatoprotective agents.

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What this paper is about

Liver damage can be induced by drugs or chemicals resulting from overdose or workplace exposure. Bromobenzene is an efficient model to perform studies on hepatotoxicity. After biotransformation into liver,it causes production of reactive oxygen species (ROS). Organs that have been found to be affected due to bromobenzene induced toxicity are liver, kidney and lungs. In the following review, mechanisms and various genes involved in the bromobenzene induced hepatotoxicity have been discussed. Also, the toxicokinetics, involving absorption, metabolism and elimination of bromobenzene from the body have been reviewed in this article. Various herbal extracts and chemicals have been found to exhibit protective effect against bromobenzene induced liver injury proving their potential in use as hepatoprotective agents.

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Available abstract

Liver damage can be induced by drugs or chemicals resulting from overdose or workplace exposure. Bromobenzene is an efficient model to perform studies on hepatotoxicity. After biotransformation into liver,it causes production of reactive oxygen species (ROS). Organs that have been found to be affected due to bromobenzene induced toxicity are liver, kidney and lungs. In the following review, mechanisms and various genes involved in the bromobenzene induced hepatotoxicity have been discussed. Also, the toxicokinetics, involving absorption, metabolism and elimination of bromobenzene from the body have been reviewed in this article. Various herbal extracts and chemicals have been found to exhibit protective effect against bromobenzene induced liver injury proving their potential in use as hepatoprotective agents.

Key concepts: Bromobenzene, Hepatotoxin, Biotransformation, Liver injury, Pharmacology, Reactive oxygen species, Toxicokinetics, Toxicity

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