2011•대한구강악안면병리학회지Requires access
Expression of E-cadherin/β-catenin Cell Adhesion Complex in Squamous Cell Carcinoma of Tongue and their Role in Prognosis, Metastasis and Recurrence
KM Ahsan Kabir, 김서연, 임원봉, 김지선, 고영종, 김상우, 오미라, 오희균, 최홍란, 김옥준
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Abstract
Recurrence-metastasis status of squamous cell carcinoma of tongue is a challenging oncologic problem. This study examined the expression of E-cadherin/β-catenin cell adhesion complex in squamous cell carcinoma of the tongue through an immunohistochemical study. Twenty samples from 15 patients with squamous cell carcinoma of the tongue, who were treated at the Department of Oral and Maxillofacial Surgery, consisted of primary or recurrent tumors along with matched metastatic lymph nodes were retrieved for immunohistochemical staining and grouped based on recurrence-metastasis status.Differences in stain localization were noted in E-cadherin, β?catenin and phospho β?catenin staining between different tumor groups based on the recurrence-metastasis status. The number of phospho β-catenin stain positive cells was found to have a significant role in survival. E-cadherin confirms its role as a powerful individual differentiation indicator and the role of β-catenin specially the phospho type elicts interest.