1981•Tropical medicineRequires access

Comparison of immunological, biological and biochemical properties of Japanese encephalitis virus strains isolated in Japan and China.

E. Y. Jin, Mikio Kobayashi, T. Ogata, T. Kitano, A. Oya

Abstract

Two Chinese strains of Japanese encephalitis virus (JEV), A2 and P3 were compared with three Japanese strains, Nakayama-NIH, Mie 44-1 and JaGAr-01 by antibody-absorption test and hemagglutination (HA) test. Structural polypeptides were analyzed by polyacrylamide gel electrophoresis. A2 and Nakayama-NIH strains were found to possess specific antigens in addition to commonantigens. However, Mie 44-1 and A2 were found to have almost the same antigenicity. Hemagglutinins of A2, P3 and Nakayama-NIH showed optimum pH at 6.4 or lower and stable for heating at 37•Ž•D JaGAr-01 strain possessing optimum pH at 6.8 or higher was unstable for heating. In spite of these biological and immunological differences, analysis of the structural polypeptides by polyacrylamide gel electrophoresis showed no difference. 23

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Key concepts: Antigenicity, Japanese encephalitis, Hemagglutination, Virus, Polyacrylamide gel electrophoresis, Antigen, Strain (injury), Virology