2015•Journal of Biochemical and Molecular ToxicologyRequires access
Estimation of the Oxidative Stress and Molecular Damage Caused by 1‐Butyl‐3‐Methylimidazolium Bromide Ionic Liquid in Zebrafish Livers
Miao Dong, Tong Liu, Jinhua Wang, Jinhua Wang, Jun Wang, Jun Wang, Lusheng Zhu, Jun Zhang
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Abstract
The present study investigated the toxic effects of 1-butyl-3-methylimidazolium bromide ([C4 mim]Br) in zebrafish livers after exposure to 5-40 mg/L of [C4 mim]Br on days 7, 14, 21, and 28. The results showed that low levels of [C4 mim]Br exposure activated the superoxide dismutase (SOD) activity during early periods of exposure. However, high concentrations (20-40 mg/L) of [C4 mim]Br caused the inhibition of SOD, which, accordingly, led to excess reactive oxygen species and malondialdehyde. The present results indicate that [C4 mim]Br causes oxidative stress in the livers of both male and female zebrafish. Additionally, the DNA damage revealed that [C4 mim]Br has a genotoxic effect on zebrafish livers, even when the concentration of [C4 mim]Br is low (5 mg/L). The DNA damage was demonstrated by quantifying the DNA strand breakage.