Marihuana metabolites in urine of man

Single doses of hashish extract containing 20 mg. of Δ‐9‐tetrahydrocannabinol (THC) were followed by excretion of what appeared to be both cannabinol and cannabidiol but no unchanged THC. A new material in the urine appeared to be a compound related to a cannabinoid. The pattern of metabolism of cannabinoids appears to differ between different subjects. Following single doses of the same amount of THC alone, only a new drug‐related metabolite could be found in the more polar range. With repeated doses, a material in the cannabinoid range was excreted in small amounts. On the whole, repeated doses of hashish extract or THC as given in the present schedule did not lead to any significant accumulation of drug or metabolites.