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Antifungal Activity of O, 0-Bisaryl Isopropyl Phosphonates and Relationships Between Chemical Structure and Activity

Eugene Sebastian J. Nidiry, N. K. Roy

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Abstract

The fungitoxicity of twenty O, O-bisaryl isopropyl phosphonates aganst four important fungi, viz. H. oryzae, P. oryzae, A. alternate and F. solani was determined. Of these O, O-bis (2,4,5-trichlorophenyl)-and O, O-bis (pentachlorophenyl) isopropylphosphonates exhibited the highest activity. Structure-activity relationship of the phosphonates showed that changes in hydrophobicity of substituents with the phenyl ring (#x03A3;π) and molar refractivity of substituents at the para-position of the phenyl ring [MR (p)] accounted for the major percentage of variation in the fungicidal activity exhibited by the members of the series against above fungi.

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What this paper is about

The fungitoxicity of twenty O, O-bisaryl isopropyl phosphonates aganst four important fungi, viz. H. oryzae, P. oryzae, A. alternate and F. solani was determined. Of these O, O-bis (2,4,5-trichlorophenyl)-and O, O-bis (pentachlorophenyl) isopropylphosphonates exhibited the highest activity. Structure-activity relationship of the phosphonates showed that changes in hydrophobicity of substituents with the phenyl ring (#x03A3;π) and molar refractivity of substituents at the para-position of the phenyl ring [MR (p)] accounted for the major percentage of variation in the fungicidal activity exhibited by the members of the series against above fungi.

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Available abstract

The fungitoxicity of twenty O, O-bisaryl isopropyl phosphonates aganst four important fungi, viz. H. oryzae, P. oryzae, A. alternate and F. solani was determined. Of these O, O-bis (2,4,5-trichlorophenyl)-and O, O-bis (pentachlorophenyl) isopropylphosphonates exhibited the highest activity. Structure-activity relationship of the phosphonates showed that changes in hydrophobicity of substituents with the phenyl ring (#x03A3;π) and molar refractivity of substituents at the para-position of the phenyl ring [MR (p)] accounted for the major percentage of variation in the fungicidal activity exhibited by the members of the series against above fungi.

Key concepts: Isopropyl, Antifungal, Ring (chemistry), Stereochemistry, Chemistry, Fungicide, Medicinal chemistry, Chemical structure

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