LIPOSOMES AS TARGETTED DRUG DELIVERY SYSTEMS PRESENT AND FUTURE PROSPECTIVES: A REVIEW

Liposomes are the leading drug delivery systems have played a significant role in the formulation of potent drug to improve therapeutic effect. The mechanism giving rise to therapeutic advantages of liposomes such as the ability of long circulating liposomes to preferentially accumulate at disease sites such as tumours, site of infection, and site of inflammation. There are several new methods of liposomes preparation based on lipid drug interaction and liposomes disposition mechanism including the incubation of rapid clearance of liposomes by controlling particle size, and surface hydration. The liposomes are characterised with respect to physical, chemical and biological parameters. Present applications of liposomes are in field of immunology, dermatology, vaccine adjuvant, eye disorder, and brain targeting therapy. This review would be helpful to the researches working in the area of liposomal drug delivery and educates how this success is being built on to design, effective carriers for genetic drugs. KEY WORDS: Liposome, drug carrier, targeted site, phospholipids, characterisation.