UJI POTENSI DAYA ANTIBAKTERI SENYAWA FENANTROLIN 1 TERHADAP ISOLAT KLINIS BAKTERI SALMONELLA TYPHI SECARA IN VITRO

Background: Salmonella typhi is one of the most common causes of gastrointestinal infections in Indonesia. Improper use of antibiotics contributes to the rise of resistance problems in the treatment of Salmonella typhi infection. The development of new antibiotics is needed as part of efforts to tackle the problem of bacterial resistance against the existing antibiotics. Phenanthroline 1 is a new compound that is synthesized from 1,10-phenanthroline compound. Based on previous studies, 1,10-phenantroline has quality as an antibacterial compound. Objective: To determine the potency of a new antibacterial compound derived from 1,10-Phenanthroline (Phenanthroline 1) against clinical isolates of Salmonella typhi by establishing the value of the Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC). Method: Descriptive experimental design is used in this study and Macrobroth Dilution method is chosen to determine the antibacterial potency of Phenanthroline 1 compound against Salmonella typhi. Result: Based on the experiments, Phenanthroline 1 has the Minimum Inhibitory concentration (MIC) at 100 I¼g/ml and Minimum Bactericidal Concentration (MBC) at 200 I¼g/ml against clinical isolates of Salmonella typhi. Conclusion: Phenanthroline 1 compound is, at a certain concentration, capable of inhibiting and killing clinical isolates of Salmonella typhi in in vitro environment.