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2010•PubMedOpen access

Proarrhythmia Induced by Propafenone: What is the Mechanism?

Francisco Femenía, Jorge Palazzolo, Mauricio Arce, Martín Arrieta

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Abstract

Propafenone, a Class IC antiarrhythmic drug, is an orally active sodium channel-blocking agent. It is effective in supraventricular tachyarrhythmias and is particularly useful in converting atrial fibrillation to sinus rhythm. In therapeutic doses, it may cause non-cardiac and cardiac toxicity, including proarrhythmia.

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What this paper is about

Propafenone, a Class IC antiarrhythmic drug, is an orally active sodium channel-blocking agent. It is effective in supraventricular tachyarrhythmias and is particularly useful in converting atrial fibrillation to sinus rhythm. In therapeutic doses, it may cause non-cardiac and cardiac toxicity, including proarrhythmia.

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Available abstract

Propafenone, a Class IC antiarrhythmic drug, is an orally active sodium channel-blocking agent. It is effective in supraventricular tachyarrhythmias and is particularly useful in converting atrial fibrillation to sinus rhythm. In therapeutic doses, it may cause non-cardiac and cardiac toxicity, including proarrhythmia.

Key concepts: Proarrhythmia, Propafenone, Medicine, Supraventricular arrhythmia, Sinus rhythm, Torsades de pointes, Cardiology, Atrial fibrillation

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