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Search For a Biomarker For The Diagnosis And Prognosis of Rheumatoid Arthritis

Ganesh K. Prasanth, Sunil Rao Padmaraj, T. Poongodi Vijayakumar, Riju Mathew

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Abstract

Rheumatoid Arthritis (RA) is one of the commonest systemic autoimmune disease. Diagnosis of Rheumatoid Arthritis is based on the detection of Rheumatoid factor (RF) and Anti cyclic citrullinated peptide Antibody (ACCP).But these markers have limited use in predicting the prognosis of the disease. Hematological and Inflammatory markers are indicators of disease activity.Correlation of the various biomarkers would be beneficial in effective treatment and management of the condition.An attempt is being made to correlate the conventional markers like RF and ACCP with the newer marker Anti Sa Antibody (Anti Sa) and hematological parameters such as Hemoglobin (Hb) , Red cell Distribution Width (RDW) and Erythrocyte Sedimentation Rate (ESR).It was observed that these parameters together serve as better biomarkers for the diagnosis and prognosis of RA. Index terms

About this research paper

What this paper is about

Rheumatoid Arthritis (RA) is one of the commonest systemic autoimmune disease. Diagnosis of Rheumatoid Arthritis is based on the detection of Rheumatoid factor (RF) and Anti cyclic citrullinated peptide Antibody (ACCP).But these markers have limited use in predicting the prognosis of the disease. Hematological and Inflammatory markers are indicators of disease activity.Correlation of the various biomarkers would be beneficial in effective treatment and management of the condition.An attempt is being made to correlate the conventional markers like RF and ACCP with the newer marker Anti Sa Antibody (Anti Sa) and hematological parameters such as Hemoglobin (Hb) , Red cell Distribution Width (RDW) and Erythrocyte Sedimentation Rate (ESR).It was observed that these parameters together serve as better biomarkers for the diagnosis and prognosis of RA. Index terms

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Available abstract

Rheumatoid Arthritis (RA) is one of the commonest systemic autoimmune disease. Diagnosis of Rheumatoid Arthritis is based on the detection of Rheumatoid factor (RF) and Anti cyclic citrullinated peptide Antibody (ACCP).But these markers have limited use in predicting the prognosis of the disease. Hematological and Inflammatory markers are indicators of disease activity.Correlation of the various biomarkers would be beneficial in effective treatment and management of the condition.An attempt is being made to correlate the conventional markers like RF and ACCP with the newer marker Anti Sa Antibody (Anti Sa) and hematological parameters such as Hemoglobin (Hb) , Red cell Distribution Width (RDW) and Erythrocyte Sedimentation Rate (ESR).It was observed that these parameters together serve as better biomarkers for the diagnosis and prognosis of RA. Index terms

Key concepts: Erythrocyte sedimentation rate, Rheumatoid arthritis, Rheumatoid factor, Medicine, Red blood cell distribution width, Biomarker, Immunology, Internal medicine

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