1998•Unpublished venueRequires access
Short reports Hyperosmolar nonketotic comaprecipitated by lithium-induced nephrogenic diabetes insipidus
Hafiz Ghufran, RW Newton
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Abstract
Summary A 45-year-old man,witha10-year history ofmanicdepression treated withlithium, wasadmitted withhyperosmolar, nonketotic coma.He gaveafive-year history of polyuria and polydipsia, duringwhich timeurinalysis hadbeennegative forglucose.Afterrecovery fromhyperglycaemia,heremained polyuric despite normal bloodglucose concentrations; waterdeprivation testing indicated nephrogenic diabetes insipidus, likely tobelithiuminduced. We hypothesize thatwhenthis man developed type2 diabetes, chronic polyuria due to nephrogenic diabetes insipidus was sufficient to precipitate hyperosmolar dehydration.