1991•Unpublished venueRequires access

InVitro Susceptibility oftheFishPathogen Aeromonas salmonicida toFlumequine

Andrew C. Barnes, C. S. Lewin, T. S. Hastings, S. G. B. Amyes

Abstract

Theactivity ofthefluoroquinolone flumequine was investigated against thefish pathogen Aeromonas salmonicida andwas compared withthat ofoxolinic acid. Flumequine was more active thanoxolinic acidin termsofitsMICagainst oxolinic acid-resistant isolates ofA.salmonicida andwas asactive asoxolinic acid against susceptible isolates. Incontrast tooxolinic acid, flumequine was bactericidal, withonly 1% ofthe bacteria surviving 6hofexposuretothedrugatconcentrations slightly above theMIC.Mutation toresistance toflumequine wasfound tooccuratalower frequency thanthat tooxolinic acid. Hence, invitro, flumequine appearstopossesssome advantages overoxolinic acidagainst this fish pathogen.

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Key concepts: Flumequine, Aeromonas salmonicida, Oxolinic acid, Microbiology, Pathogen, Biology, Bacteria, Chemistry