2013•Unpublished venueRequires access

Urokinase - type Plasminogen Activator System in Human Breast Cancer

Reyadh Salim Al-Jubouri, Faeza Aftan Al-Rawi, Ali H. Al-Khafaji

Abstract

Urokinase plasminogen activator (uPA), urokinase plasminogen activator receptor (uPAR) and plasminogen activator inhibitor-1(PAI-1) are essential for metastasis, and overexpression of these molecules is strongly correlated with poor prognosis in a variety of malignant tumors. This study revealed direct correlation between immunohistochemical expression of uPA with pathological stage. No significant association of immunohistochemical expressions of uPA, uPAR and PAI1 with immunohistochemical expressions for estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor -2 (HER-2/neu), and direct association between immunohistochemical expressions of (uPA and uPAR) as well as between immunohistochemical expressions of (uPA and PAI-1). Keyword: Breast cancer, uPA, uPAR ,PAI-1, Tissue microarray

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Key concepts: Urokinase receptor, Immunohistochemistry, Plasminogen activator, Urokinase, Tissue microarray, Cancer research, Breast cancer, Estrogen receptor