Hu-CD8/CD38/CD3/HLA-DR 4 Color FCM Reagent: sc-2910

BACKGROUND Human CD8/CD38/CD3/HLA-DR: sc-2910 is a direct immunofluorescence reagent formatted to identify the percentage of activated T-suppressor/cytotoxic lymphocytes (1) in erythrocytelysed whole blood, based on cell-surface antigen expression. CD8 identifies suppressor/cytotoxic T lymphocytes and binds class I MHC molecules, which enhances the activation of resting T lymphocytes (2). CD38 is expressed during the early and final stages of T and B cell differentiation, but not during the intermediate stage (3). CD3 identifies T lymphocytes and noncovalently associates with either α/β or γ/δ TCR (4). HLA-DR is expressed on B lymphocytes, monocytes, macrophages, activated T lymphocytes and human progenitor cells (5). Reductions in the percentage and absolute number of CD4+ cells, as well as abnormally high levels of activated peripheral T cells and an increased proportion of CD8+ cells coexpressing CD57 (involved in NK activity) have been reported in HIV infection and associated with disease progression (1).