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IN VITRO SUSCEPTIBILITY OF METHICILLIN-RESISTANT STAPHYLOCCOCCUS AUREUS TO LINEZOLID BY E-TEST METHOD

Nükhet Kurultay

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Abstract

SUMMARY The incidence of methicillin-resistant gram-positive infections continue to increase and linezolid may provide new options to treat patients. The aim of this study was to investigate the in vitro susceptibility of methicillin-resistant Staphylococcus aureus (MRSA) strains isolated from clinical specimens to linezolid. The in vitro susceptibility of a total of 88 MRSA isolates to linezolid was investigated by the E-test. All MRSA isolates were found to be susceptible to linezolid (Minimal inhibitory concentration < 4.0 mg/l). The results of the present study demonstrated that linezolid has a good in vitro activity against MRSA in Turkey. This drug could be a promising therapeutic option against MRSA.

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What this paper is about

SUMMARY The incidence of methicillin-resistant gram-positive infections continue to increase and linezolid may provide new options to treat patients. The aim of this study was to investigate the in vitro susceptibility of methicillin-resistant Staphylococcus aureus (MRSA) strains isolated from clinical specimens to linezolid. The in vitro susceptibility of a total of 88 MRSA isolates to linezolid was investigated by the E-test. All MRSA isolates were found to be susceptible to linezolid (Minimal inhibitory concentration < 4.0 mg/l). The results of the present study demonstrated that linezolid has a good in vitro activity against MRSA in Turkey. This drug could be a promising therapeutic option against MRSA.

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Available abstract

SUMMARY The incidence of methicillin-resistant gram-positive infections continue to increase and linezolid may provide new options to treat patients. The aim of this study was to investigate the in vitro susceptibility of methicillin-resistant Staphylococcus aureus (MRSA) strains isolated from clinical specimens to linezolid. The in vitro susceptibility of a total of 88 MRSA isolates to linezolid was investigated by the E-test. All MRSA isolates were found to be susceptible to linezolid (Minimal inhibitory concentration < 4.0 mg/l). The results of the present study demonstrated that linezolid has a good in vitro activity against MRSA in Turkey. This drug could be a promising therapeutic option against MRSA.

Key concepts: Linezolid, Staphylococcus aureus, Microbiology, In vitro, Medicine, Methicillin-resistant Staphylococcus aureus, Minimum inhibitory concentration, Antibiotics

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