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2015•Journal for ImmunoTherapy of CancerOpen access

Tumor response from durvalumab (MEDI4736) + tremelimumab treatment in patients with advanced non-small cell lung cancer (NSCLC) is observed regardless of PD-L1 status

Naiyer A. Rizvi, Jamie E. Chaft, Ani Sarkis Balmanoukian, Sarah B. Goldberg, Rachel E. Sanborn, Keith E. Steele, Marlon Cezar Rebelatto, Yu Lan Gu, Joyson Joseph Karakunnel, Scott Joseph Antonia

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Abstract

Meeting abstracts As single agents, durvalumab (MEDI4736), a human IgG1 anti-PD-L1 antibody, and tremelimumab, a human IgG2 anti-CTLA-4 antibody, have shown acceptable safety profiles and antitumor activity. Similar to other anti-PD-L1/anti-PD-1 monotherapies, durvalumab has shown greater objective

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What this paper is about

Meeting abstracts As single agents, durvalumab (MEDI4736), a human IgG1 anti-PD-L1 antibody, and tremelimumab, a human IgG2 anti-CTLA-4 antibody, have shown acceptable safety profiles and antitumor activity. Similar to other anti-PD-L1/anti-PD-1 monotherapies, durvalumab has shown greater objective

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Available abstract

Meeting abstracts As single agents, durvalumab (MEDI4736), a human IgG1 anti-PD-L1 antibody, and tremelimumab, a human IgG2 anti-CTLA-4 antibody, have shown acceptable safety profiles and antitumor activity. Similar to other anti-PD-L1/anti-PD-1 monotherapies, durvalumab has shown greater objective

Key concepts: Durvalumab, Tremelimumab, Medicine, Antibody, Oncology, Immunotherapy, PD-L1, Internal medicine

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Tumor response from durvalumab (MEDI4736) + tremelimumab treatment in patients with advanced non-small cell lung cancer (NSCLC) is observed regardless of PD-L1 status — Research Paper | ScholarLens