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COMPARISON OF RADIOBIOLOGICAL EFFECTS OF CARBON IONS TO PROTONS ON A RESISTANT HUMAN MELANOMA CELL LINE

I. Petrovi, A. Risti, G.A.P. Cirrone, G. Cuttone

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Abstract

Radiobiological parameters were assessed after irradiation of HTB140 melanoma cells with 62 MeV/u 12 C ions or protons along Bragg curve. Due to higher linear energy transfer (LET), better efficiency of 12 C ions compared to protons was revealed through surviving fraction and relative biological effectiveness. Significant cell inactivation on distal declining end of Bragg peak was higher for 12 C ions. Protons, close to Bragg peak maximum, having lower LET, produce reparable damages to affected cells, thus lower proliferation than 12 C ions. Higher LET of 12 C ions causes more irreparable damages, giving higher proliferation activity.

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What this paper is about

Radiobiological parameters were assessed after irradiation of HTB140 melanoma cells with 62 MeV/u 12 C ions or protons along Bragg curve. Due to higher linear energy transfer (LET), better efficiency of 12 C ions compared to protons was revealed through surviving fraction and relative biological effectiveness. Significant cell inactivation on distal declining end of Bragg peak was higher for 12 C ions. Protons, close to Bragg peak maximum, having lower LET, produce reparable damages to affected cells, thus lower proliferation than 12 C ions. Higher LET of 12 C ions causes more irreparable damages, giving higher proliferation activity.

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Available abstract

Radiobiological parameters were assessed after irradiation of HTB140 melanoma cells with 62 MeV/u 12 C ions or protons along Bragg curve. Due to higher linear energy transfer (LET), better efficiency of 12 C ions compared to protons was revealed through surviving fraction and relative biological effectiveness. Significant cell inactivation on distal declining end of Bragg peak was higher for 12 C ions. Protons, close to Bragg peak maximum, having lower LET, produce reparable damages to affected cells, thus lower proliferation than 12 C ions. Higher LET of 12 C ions causes more irreparable damages, giving higher proliferation activity.

Key concepts: Bragg peak, Linear energy transfer, Relative biological effectiveness, Ion, Irradiation, Melanoma, Proton, Radiochemistry

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