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FULL LENGTH RESEARCH PAPER Hypotensive Effect of Ethanolic Seed Extract of Hibiscus sabdariffa Linn (Malvaceae) on Normotensive Cats

Morbid Anatomy

Abstract

The hypotensive effects of ethanolic seed extract of Hibiscus sabdariffa l. were evaluated in normotensive cats. The effects of the ethanolic extract were compared with normal basal rhythm and Acetylcholine. The standard drugs Ach and various doses of the extracts (1mg/ml, 5mg/ml and 10mg/ml) were injected through a cannula inserted in the femoral artery. The extract produced a significant (P<0.05) reduction in cat blood pressure. The potency of the extract seems to be high because it has activity at the minimum dose used. The 1mg/ml of the extract exhibited more effective response; however the standard drug Acetylcholine showed a greater potency than the extract. The seed extracts are characterized by low degree of toxicity with LD50 above 5000mg/kg in rats.

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Key concepts: Hibiscus sabdariffa, Potency, Acetylcholine, Pharmacology, Hibiscus, Blood pressure, Traditional medicine, Malvaceae