FORMULATION AND IN-VITRO EVALUATION OF NOVEL ATORVASTATIN - AMLODIPINE ORODISPERSIBLE TABLETS

The purpose of study was to fabricate rapid acting tablets for traveling, unconscious and unresponsive hypertensive patients thereby improving patient compliance, decreasing cost of the treatment and number of pills. Novel antihypertensive orodispersible tablets (ODT’s) of amlodipine and atorvastatin were prepared by direct compression and sublimation technique. Kyron T134 and Crosscaramellose sodium were used as superdisintegrant. Ten formulations (F1F10) were prepared by varying superdisintegrants concentration to optimize the best formulation. Pre-compression studies like Bulk density, Tapped density, Angle of repose, Carr’s compressibility index, Hausner’s ratio to note flow properties of powder and compatibility studies such as Fourier Transform Infrared Red spectroscopy (FTIR) and Differential Scanning Calorimetry (DSC) were performed to check any interaction between drugs and superdisintegrants. Then after flow and compressibility studies powder was compressed into ODT’s. Various features such as hardness, thickness, diameter, weight variation, friability, disintegration time, dissolution studies, wetting time, wetting volume, water absorption ratio, modified disintegration time, uniformity of contents and stability of formulated ODT’s were