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C-Reactive Protein and Clinical Outcomes in Peritoneal Dialysis Patients

Morrell M. Avram, Paul A. Fein, Márlon Paluch, Jyoti P. Chattopadhyay

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Abstract

r = ‐0.47, p < 0.0001) and creatinine (r = ‐0.35, p = 0.006) were associated with a higher level of CRP. Enrollment hs-CRP was a significant predictor of mortality in PD patients (relative risk = 1.044, p = 0.023). The observed cumulative survival (Kaplan‐Meier) of patients with hs-CRP < 15 mg/L was significantly better (p = 0.007) than was the survival of patients with a hs-CRP ♢ 15 mg/L. In a multivariate regression analysis, serum prealbumin was the best and only significant predictor of CRP level (β = ‐0.37, p = 0.005). Elevated CRP was associated with infection and inflammation. Therefore, routine testing of hs-CRP in PD patients should be considered.

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What this paper is about

r = ‐0.47, p < 0.0001) and creatinine (r = ‐0.35, p = 0.006) were associated with a higher level of CRP. Enrollment hs-CRP was a significant predictor of mortality in PD patients (relative risk = 1.044, p = 0.023). The observed cumulative survival (Kaplan‐Meier) of patients with hs-CRP < 15 mg/L was significantly better (p = 0.007) than was the survival of patients with a hs-CRP ♢ 15 mg/L. In a multivariate regression analysis, serum prealbumin was the best and only significant predictor of CRP level (β = ‐0.37, p = 0.005). Elevated CRP was associated with infection and inflammation. Therefore, routine testing of hs-CRP in PD patients should be considered.

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Available abstract

r = ‐0.47, p < 0.0001) and creatinine (r = ‐0.35, p = 0.006) were associated with a higher level of CRP. Enrollment hs-CRP was a significant predictor of mortality in PD patients (relative risk = 1.044, p = 0.023). The observed cumulative survival (Kaplan‐Meier) of patients with hs-CRP < 15 mg/L was significantly better (p = 0.007) than was the survival of patients with a hs-CRP ♢ 15 mg/L. In a multivariate regression analysis, serum prealbumin was the best and only significant predictor of CRP level (β = ‐0.37, p = 0.005). Elevated CRP was associated with infection and inflammation. Therefore, routine testing of hs-CRP in PD patients should be considered.

Key concepts: Medicine, C-reactive protein, Internal medicine, Peritoneal dialysis, Gastroenterology, Creatinine, Multivariate analysis, Dialysis

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