ANALGESIC ACTIVITY OF ROOT EXTRACT OF SOLANUM MELONGENA LINN ROOT

The present study was aimed at Pharmacognostic study and biological evaluation of analgesic activity of plants roots. The roots of plants were studies fo r Pharmacognostic characteristics namely, morphology, microscopy, physicochemical parameters, which can be of utilized in identifi cation/authentication of the plant and/or its roots in crude drug form. The preliminary phytochemical screening of the dry residue was carried out by the chemical test and thin layer chromatographi c method. The preliminary phytochemical screening of dry residue showed the presence of Saponins, Alkaloids, Glycoside, and Flavonoids in various extracts. However most of the medici nally potential phytoconstituents were present in methanolic and aqueous extracts. The Hydroalcoholic extract was selected for Biol ogical screening due to high alcoholic - soluble extractive value, high yield of successive alcoholic extract and TLC results. The analgesic screening was done using Hot plate method, Tail immersion methods and acetic acid ind uced in rats and mice. Hydroalc oholic extract was administered orally at the acute doses of 200mg/kg and 400mg/kg b.w. Several activities on these doses hav e already been reported. Both the doses showed significant (p<0.05) analgesic activity.