EVALUATION OF ANTI-DIABETIC AND HEPATO PROTECTIVE ACTIVITY OF 95% METHANOLIC EXTRACT OF TERMINALIA TOMENTOSA BARK BY USING ALBINO RATS

The anti-diabetic and hepatoprotective activity of the Methanolic extract of the bark of Terminalia tomentosa (family: combrataceae) was investigated on alloxan induced diabetic albino rats. A comparison was made between both plant extract and a known antidiabetic drug glibenclamide (5mg/kg -1 ). The dried bark of Terminalia tomentosa was subjected to extraction by continuous hot extraction method using methanol as a solvent. Phytochemical estimation was done for the presence of phytoconstituents. Dose selection was made on the basis of acute oral toxicity study (250mg/kg -1 , 500mg/kg -1 bodyweight) as per OECD guidelines. Oral administration of extract of Terminalia tomentosa for 21days resulted in significant reduction in blood glucose level. Alloxan induced diabetic rat model and oral glucose tolerance test (OGTT) model was used for evaluation of antidiabetic activity. The biochemical parameters were analysed. All rats in the diabetic groups had FBG levels well within the diabetic range (>150 mg dL -1 ) at the initial stage of the experiment but after three weeks of treatment with extracts or glibenclamide the FBG significantly dropped in dose-dependent manner, and also correct the lipid profile and liver enzymes. The results suggest that the Methanol extracts of the bark of Terminalia tomentosa restored the metabolic changes in alloxan-induced diabetic rats.