Preparation and Release Characterization of Biodegradable Poly(є-caprolactone) Microcapsules Containing Tocopherol

The biodegradable poly(є-caprolactone) (PCL) microcapsules containing tocopherol were pre- pared by oil-in-water emulsion solvent evaporation method. The features of the microcapsules were in- vestigated in the manufacturing conditions and degradation behaviors. The form and structural feature of the microcapsules were measured by scanning electron microscope and X-ray diffraction, respectively. The surface free energy of the microcapsules was executed using contact angle measurement. As a result, the microcapsules were more stable and spherical with poly(vinyl alcohol) given in a surfactant. The surface free energy and crystallinity of microcapsules were decreased with increasing the core concentration, and degradation of PCL was occurred after 21 days. The release behaviors were examined by UV/vis. spectrophotometer. It was found that the release rate of the microcapsules was increased with increasing the stirring rate, due to the increased interface between microcapsules and release media.