1998•PhysiologyRequires access

Understanding the Role of Paracellular Transport in the Proximal Tubule

Néstor H. García, Carla R. Ramsey, Franklyn G. Knox

Abstract

Fluid and solute reabsorption by the proximal tubule is the result of both transcellular and paracellular flux. The role of transcellular transport has been extensively studied, but the importance of paracellular flux has not been as thoroughly investigated. The purpose of this review is to update concepts about the contribution of paracellular transport for reabsorption by the proximal tubule.

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Key concepts: Paracellular transport, Transcellular, Reabsorption, Proximal tubule, Renal tubule, Tubule, Chemistry, Claudin