Research Article Bioavailability Studies of Paracetamol and Ibuprofen in Single and Combination Dosage in Experimental Rabbits

The main of our work is to study the bioavailability of ibuprofen and paracetamol when given in combination to the rabbits. Single oral dose of 46.0 mg/kg ibuprofen and 56.0 mg/kg of paracetamol were administered separately to two groups of animals and a combination of the same doses was given orally to a III group. Serum level of the drugs in all the three groups were measured spectrophotometrically. The serum peak concentration and rate of elimination of paracetamol is significantly reduced when given with ibuprofen. No such alternation was noticed in serum ibuprofen with paracetamol. Lower elimination rate of paracetamol may increase the effectiveness for a longer time.