COMPARATIVE STUDY OF DISINTEGRANTS IN FORMULATION OF CEFADROXIL DISPERSIBLE TABLETS

Summary Dispersible cefadroxil tablets were prepared employing three disintegrants, croscarmellose sodium, crospovidone and sodium starch glycolate in two separate quantities separately along with microcrystalline cellulose. Direct compression method was followed for all formulations. Thus six formulations (F1-F6) were prepared and compared among themselves and with one marketed product (MP) in evaluations. Evaluations for precompressional parameters like angle of repose, compressibility and hardness ratio were done. Evaluations for post compressional parameters like weight variation, thickness, hardness, friability, disintegration time, dispersion time, wetting time, assay and dissolution study were carried out. Formulation containing 26.25 mg of croscarmellose sodium per tablet was found suitable and better than marketed and formulated tablets in disintegration time, dispersion time and dissolution study.