Formulation and Evaluation of Sustained Release Matrix Tablets of Ambroxol Hydrochloride

Oral sustained release matrix tablets of Ambroxol HCl were formulated in order to improve efficacy, reduce the frequency of administration, and better patient compliance. The overall objective of the present work was to develop an oral sustained release Ambroxol HCl tablets prepared by direct compression method, using hydrophilic hydroxyl propyl methylcellulose and hydrophobic ethyl cellulose polymer as a rate controlling factor. All the batches were evaluated for thickness, weight variation, hardness, and drug content uniformity and in vitro drug release. Mean dissolution time is used to characterize the drug release rate from a dosage form and indicates the drug release retarding efficiency of polymer.