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2013•Journal of Clinical Case ReportsRequires access

Small Cell Neuroendocrine Carcinoma of the Uterine Cervix to Analysis of 3 Cases

Aurélie Pelissier- Komorek

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Abstract

Background: Histopathologically similar to small cell carcinoma of lung, small cell neuroendocrine carcinoma of the cervix is a rare malignancy with an aggressive behavior, due to an early lymphatic involvement and hematogenous dissemination. Pelvic recurrence and distant metastasis are very common. In literature, the best treatment modality remains controversial. Cases: From a series of 3 cases and a literature review, we focus on screening, prognostic factors and treatment of this cancer. Conclusion: Human Papilloma Virus (HPV) 18 infection seems to be specifically related to small cell neuroendocrine carcinoma. Screening with HPV genotyping, and a multimodal therapy could improve the prognosis of these patients.

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What this paper is about

Background: Histopathologically similar to small cell carcinoma of lung, small cell neuroendocrine carcinoma of the cervix is a rare malignancy with an aggressive behavior, due to an early lymphatic involvement and hematogenous dissemination. Pelvic recurrence and distant metastasis are very common. In literature, the best treatment modality remains controversial. Cases: From a series of 3 cases and a literature review, we focus on screening, prognostic factors and treatment of this cancer. Conclusion: Human Papilloma Virus (HPV) 18 infection seems to be specifically related to small cell neuroendocrine carcinoma. Screening with HPV genotyping, and a multimodal therapy could improve the prognosis of these patients.

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Available abstract

Background: Histopathologically similar to small cell carcinoma of lung, small cell neuroendocrine carcinoma of the cervix is a rare malignancy with an aggressive behavior, due to an early lymphatic involvement and hematogenous dissemination. Pelvic recurrence and distant metastasis are very common. In literature, the best treatment modality remains controversial. Cases: From a series of 3 cases and a literature review, we focus on screening, prognostic factors and treatment of this cancer. Conclusion: Human Papilloma Virus (HPV) 18 infection seems to be specifically related to small cell neuroendocrine carcinoma. Screening with HPV genotyping, and a multimodal therapy could improve the prognosis of these patients.

Key concepts: Medicine, Cervix, Uterine cervix, Omics, Carcinoma, Gynecology, Neuroendocrine carcinoma, Pathology

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